Title of article
Cinchona alkaloid/TMAF combination: Enantioselective trifluoromethylation of aryl aldehydes
Author/Authors
Kawai، نويسنده , , Hiroyuki and Mizuta، نويسنده , , Satoshi and Tokunaga، نويسنده , , Etsuko and Shibata، نويسنده , , Norio، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2013
Pages
5
From page
46
To page
50
Abstract
The catalytic enantioselective trifluoromethylation reaction of aromatic aldehydes using the Ruppert–Prakash reagent (Me3SiCF3) has been disclosed, with an operationally simple procedure, based on the combination of sterically demanding cinchona alkaloid-derived phase-transfer catalyst 3b with tetramethylammonium fluoride (TMAF). Our methodology provides medicinally important α-trifluoromethyl alcohols with high chemical yields and moderate to good enantioselectivities (50–70% ee).
Keywords
aldehyde , Chiral catalysis , enantioselective , trifluoromethylation , Phase-transfer catalysts
Journal title
Journal of Fluorine Chemistry
Serial Year
2013
Journal title
Journal of Fluorine Chemistry
Record number
1612039
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