Mg–Cu bimetal system for selective CF bond activation

Bimetal system of Mg–CuCl in DMI for selective CF and CCl bonds activation has been examined. This article involves (1) a short overview of bimetal system of Mg-metals for selective CF bond activation, (2) CF bond activation of alkyl trifluoroacetates leading to alkyl difluoro(trimethylsilyl)acetates via difluoroketene silyl acetal, (3) selective CCl bond activation of 3- and 4-chloropentafluoroethylbenzenes, (4) CF bond activation of substituted benzotrifluorides and (5) microscopic observation of an active site of magnesium surface formed in Mg–CuCl system and elucidation of reaction mechanism of CCl and CF bond activation at the active site.