Title of article
Caspase-2 cleaves DNA fragmentation factor (DFF45)/Inhibitor of caspase-activated DNase (ICAD)
Author/Authors
Dahal، نويسنده , , Giri Raj and Karki، نويسنده , , Pratap and Thapa، نويسنده , , Arjun and Shahnawaz، نويسنده , , Mohammad and Shin، نويسنده , , Song Yub and Lee، نويسنده , , Jung Sup and Cho، نويسنده , , Byungyun and Park، نويسنده , , Il-Seon، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
134
To page
139
Abstract
To investigate the signal transduction pathway of caspase-2, cell permeable Tat–reverse-caspase-2 was constructed, characterized and utilized for biochemical and cellular studies. It could induce the cell death as early as 2 h, and caspase-2-specific VDVADase activity but not other caspase activities including DEVDase and IETDase. Interestingly, nuclear DNA fragmentation occurred and consistently DNA fragmentation factor (DFF45)/Inhibitor of caspase-activated DNase (ICAD) was cleaved inside the cell as well as in vitro, suggesting a role of caspase-2 in nuclear DNA fragmentation.
Keywords
tat , apoptosis , DNA fragmentation factor , Caspase-2
Journal title
Archives of Biochemistry and Biophysics
Serial Year
2007
Journal title
Archives of Biochemistry and Biophysics
Record number
1628964
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