Title of article
Vitamin D 25-hydroxylase – Four decades of searching, are we there yet?
Author/Authors
Zhu، نويسنده , , Jinge and DeLuca، نويسنده , , Hector F.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2012
Pages
7
From page
30
To page
36
Abstract
Bioactivation of vitamin D3 involves 25-hydroxylation and subsequent 1α-hydroxylation to produce 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3], the active hormone. Six cytochrome P450 enzymes (CYP27A1, CYP2R1, CYP2J2/3, CYP3A4, CYP2D25 and CYP2C11) catalyzing the initial 25-hydroxylation step are reviewed, and their physiological relevance as vitamin D 25-hydroxylases in vivo is discussed.
Keywords
CYP27A1 , CYP2D25 , CYP2C11 , Cytochrome P450 enzymes , CYP3A4 , CYP2R1 , CYP2J2/3
Journal title
Archives of Biochemistry and Biophysics
Serial Year
2012
Journal title
Archives of Biochemistry and Biophysics
Record number
1632836
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