Title of article
Chemoselective acylation of hydrazinopeptides: a novel and mild method for the derivatization of peptides with sensitive fatty acids
Author/Authors
Bonnet، نويسنده , , Dominique and Rommens، نويسنده , , Corinne and Gras-Masse، نويسنده , , Hélène and Melnyk، نويسنده , , Oleg، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
45
To page
48
Abstract
N-terminal α-hydrazinoacetylpeptides were synthesized and chemoselectively acylated on the hydrazine moiety with various fatty acid succinimidyl esters or N-(cholesterylcarbonyloxy) succinimide. The acylation was performed in water/2-methyl-propane-2-ol mixtures buffered at pH 5.1. The mild reaction conditions allow the derivatization of peptides by sensitive fatty acids.
Keywords
Lipopeptide , ?-hydrazinoacetyl , hydrazinopeptide , acylation , fatty acids
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1635936
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