Asymmetric alkylation of aromatic aldehydes with diethylzinc catalyzed by a fluorous BINOL–Ti complex in an organic and fluorous biphase system

Fluorous chiral BINOL ((R)-FBINOL) was prepared by short reaction steps in good overall yield and was applied to the catalytic asymmetric alkylation in a toluene and FC-72 biphase system. The (R)-FBINOL–Ti complex in the FC-72 phase was consecutively reused in the biphase system and the enantioselectivity was still higher than 80% ee at the 5th reaction.