Title of article
Regioselective nitration of purine nucleosides: synthesis of 2-nitroadenosine and 2-nitroinosine
Author/Authors
Paymaneh Y.F Deghati، نويسنده , , Paymaneh Y.F and Wanner، نويسنده , , Martin J and Koomen، نويسنده , , Gerrit-Jan، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
5
From page
1291
To page
1295
Abstract
Nitration reactions of 6-substituted purine nucleosides with tetrabutylammonium nitrate/trifluoroacetic anhydride (TBAN/TFAA) have been studied. This nitrating mixture selectively nitrates C-6 substituted purines at the 2-position, but the method is limited to substrates without NH or OH substituents. Acetylated 6-chloropurine riboside was cleanly nitrated (DCM, 0°C, 71%) and converted to nitro substituted adenosine and inosine in a few simple steps.
Keywords
Nitration , adenosine , Inosine
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1636469
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