Title of article
An investigation into the alkylation of 1,2,4-triazole
Author/Authors
Bulger، نويسنده , , Paul G and Cottrell، نويسنده , , Ian F and Cowden، نويسنده , , Cameron J and Davies *، نويسنده , , Antony J and Dolling، نويسنده , , Ulf-H، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
5
From page
1297
To page
1301
Abstract
The alkylation of 1,2,4-triazole with 4-nitrobenzyl halides and a variety of bases afforded the 1- and 4-alkylated isomers with a consistent regioselectivity of 90:10. Previously reported regiospecific alkylations of 1,2,4-triazole were re-examined and the quoted isomer ratios were shown to depend on the isolation procedure. The use of DBU as base in the alkylation of 1,2,4-triazole allows for a convenient and high yielding synthesis of 1-substituted-1,2,4-triazoles.
Keywords
4-Triazole , regioselective alkylation , Rizatriptan , DBU , 1 , 2
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1636470
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