Title of article
An efficient synthesis of 4(5),11(12)-taxadiene derivatives and microbial mediated 20-hydroxylation of taxoids
Author/Authors
Hu، نويسنده , , Shanghui and Sun، نويسنده , , Di-an and Scott، نويسنده , , A.Ian، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
3
From page
1703
To page
1705
Abstract
4(20),11(12)-Taxadiene 1 is specifically converted into 4(5),11(12)-taxadiene 5 via Claisen-like rearrangement and Barton radical desulfurization (cleavage of C–S bond) in high yield. Taxoid 5 and its deoxygenated derivatives are potential biosynthetic precursors of paclitaxel and other taxoids. 20-Hydroxylated metabolite 8 is one major product from microbially mediated hydroxylation of 5.
Keywords
radicals and radical reactions , Taxoids , Microorganisms , Rearrangement , hydroxylation , Desulfurization
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1636559
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