Title of article
Radical mediated stereoselective synthesis of chiral spiroacetals from enol-esters
Author/Authors
Sharma، نويسنده , , G.V.M and Chander، نويسنده , , A.Subash and Goverdhan Reddy، نويسنده , , V and Krishnudu، نويسنده , , K and Ramana Rao، نويسنده , , M.H.V and Kunwar، نويسنده , , A.C، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
1997
To page
2000
Abstract
Stereoselective synthesis of chiral spiroacetals starting from enol-ester 1, derived from d-manno lactone, is described. The strategy involves 1,4-addition of a variety of alcohols to 1 in the presence of NBS to give α-bromo acetals, which undergo a regio- and stereoselective radical cyclisation to give highly functionalised chiral spiroacetals.
Keywords
spiroacetals , Radical cyclisation , enol-ester , ?-bromo acetals
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1636624
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