Title of article
An NMR method for determination of configuration of β-substituted carboxylic acids
Author/Authors
Hoye، نويسنده , , Thomas R and Hamad، نويسنده , , Abdel-Sattar S and Koltun، نويسنده , , Dmitry O and Tennakoon، نويسنده , , Manomi A. Tennakoon، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
5
From page
2289
To page
2293
Abstract
The absolute configuration of the stereogenic center at the β-position of a carboxylic acid can be determined via derivatization with chiral benzylic amines [PhCH(Me)NH2 or 1-NpCH(Me)NH2]. Acids of known configuration and with a variety of β-substituents were subjected to derivatization. Analysis of the signs of the chemical shift differences of substituent protons permits determination of the absolute configuration.
Keywords
NMR spectroscopy , Stereochemistry , carboxylic acids , configuration
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1636718
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