Application of combinatorial techniques in the synthesis of unsymmetrically substituted 5,15-diphenylporphyrins

Combinatorial techniques, both solid and solution phase, have been applied to the synthesis of unsymmetrically substituted 5,15-diphenylporphyrins. 5-(4-Hydroxyphenyl)-15-pentafluorophenylporphyrin can be loaded onto solid supports and substituted on the pentafluorophenyl ring with thiols. Diversity is then expanded by cleavage and solution phase substitution of the second phenyl ring using a solid supported base.