Title of article
An expeditious liquid-phase synthesis of cyclic peptide nucleic acids
Author/Authors
Verheijen، نويسنده , , Jeroen C and Grotenbreg، نويسنده , , Gijsbert M and Hart de Ruyter، نويسنده , , Ludo and van der Klein، نويسنده , , Pieter A.M and van der Marel، نويسنده , , Gijsbert A and van Boom، نويسنده , , Jacques H، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
5
From page
3991
To page
3995
Abstract
Suitably protected linear precursors of cyclic PNAs can be readily obtained by BOP/DiPEA coupling of the corresponding sub-monomers. Conversion of the linear PNA dimers into the pentafluorophenyl esters allows cyclization by intramolecular attack of the deprotected primary amino function under diluted conditions. After removal of the secondary amino protecting group(s), installation of the required nucleobase-acetyl function(s) affords cyclic PNAs. In addition, the latter compounds can be prepared following a direct coupling strategy.
Keywords
peptide nucleic acid , cyclization , coupling reactions , Macrocycles
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1637703
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