Title of article
Tritylisation of pyrene, perylene and coronene: a new family of switchable fluorescent labels
Author/Authors
Shchepinov، نويسنده , , Mikhail S and Korshun، نويسنده , , Vladimir A and Egeland، نويسنده , , Ryan D and Southern، نويسنده , , Edwin M، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
6
From page
4943
To page
4948
Abstract
The synthesis of novel fluorescent labels based on pyrene, perylene and coronene is described. Due to the trityl-type structure, their fluorescence may be reversibly switched on and off by changing the pH. This property can be used to expand the palette of fluorophores available for multicolour DNA detection on DNA chips. Some FRET and surface chemistry applications are also demonstrated.
Keywords
Nucleic acids , Grignard reactions , Friedel–Crafts reactions , fluorescence , polycyclic aromatic compounds
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1638107
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