Title of article
Facile synthesis of (+)-biotin via Fukuyama coupling reaction
Author/Authors
Shimizu، نويسنده , , Toshiaki and Seki، نويسنده , , Masahiko، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
3
From page
5099
To page
5101
Abstract
Treatment of a thiolactone 2 with a zinc reagent 3 in the presence of PdCl2(PPh3)2 (10 mol%) allowed installation of a C-2 side chain of (+)-biotin in a highly efficient manner, which enabled synthesis of (+)-biotin in three steps from 2.
Keywords
palladium and compounds , Sulfur compounds , zinc and compounds , vitamins
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1638154
Link To Document