Title of article
A concise synthesis of AG5473/5507 utilizing N-acyliminium ion chemistry
Author/Authors
Guo، نويسنده , , Chuangxing and Reich، نويسنده , , Siegfried and Showalter، نويسنده , , Rich and Villafranca، نويسنده , , Ernie and Dong، نويسنده , , Liming، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
5
From page
5307
To page
5311
Abstract
FKBP-12 inhibitors AG5473 and AG5507 were resynthesized through a more efficient 11-step sequence. The key steps involved propargyl trimethylsilane addition to an N-acyliminium ion, ozonolysis of the allene and acid-catalyzed cyclization. A mild protocol for introducing a formaldehyde moiety to an anomeric center was established. The synthetic materials were evaluated in the FKBP rotamase assay.
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1638198
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