Title of article
Studies towards a stereocontrolled synthesis of the tricarboxylate core of the zaragozic acids–squalestatins by a cycloaddition–rearrangement strategy
Author/Authors
Hodgson، نويسنده تهران-دانشگاه صنعتي مالك اشتر Hodgson, R,D. , David M. and Villalonga-Barber، نويسنده , , Carol، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
5597
To page
5600
Abstract
Reaction of diazoketodiester 11 with methyl glyoxylate in toluene in the presence of catalytic rhodium(II) acetate gives predominantly the 6,8-dioxabicyclo[3.2.1]octane 13. Acid-catalysed rearrangement of the corresponding alcohol 14 favours at equilibrium the 2,8-dioxabicyclo[3.2.1]octane skeleton 15 of the zaragozic acids–squalestatins.
Keywords
Ylide , zaragozic acids , cycloaddition , Rearrangement
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1638257
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