Title of article
Application of Grignard reagents to the synthesis of tertiary methylamines via resin-bound oxyiminium ions
Author/Authors
Blaney، نويسنده , , Paul and Grigg، نويسنده , , Ronald and Rankovic، نويسنده , , Zoran and Thoroughgood، نويسنده , , Matthew، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
6639
To page
6642
Abstract
The solid-phase synthesis of tertiary methylamines via the nucleophilic displacement of benzotriazole Mannich adducts with Grignard reagents using a hydroxylamine linker is described. The chemistry is exemplified by the synthesis of the MAO inhibitor α-methylpargyline. Also described is the synthesis of the analgesic Tramadol by an alternative one-pot solid-phase Mannich reaction.
Keywords
ions , oxyiminium , tertiary methylamines , traceless hydroxylamine linker , benzotriazole Mannich adducts , Grignard reagents , ?-methylpargyline , Tramadol , solid-phase synthesis
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1638593
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