Use of chiral enolsilanes and chiral aldehydes in a Mukaiyama-type aldol reaction promoted by titanium(IV)isopropoxide

In the presence of a catalytic amount of titanium(IV) isopropoxide, an aldol reaction is conducted between chiral enolsilanes formed by an allyltitanation reaction and chiral aldehydes to afford ketones in high yields. These ketones were reduced and esterified by a Tischtschenko reaction to obtain esters bearing six or seven stereocenters.