Title of article
A new synthesis of 1,2,4-triazolin-5-ones: application to the convergent synthesis of an NK1 antagonist
Author/Authors
Cowden، نويسنده , , Cameron J and Wilson*، نويسنده , , Robert D and Bishop، نويسنده , , Brian C and Cottrell، نويسنده , , Ian R. L. Davies، نويسنده , , Antony J and Dolling، نويسنده , , Ulf-H، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
8661
To page
8664
Abstract
Chlorotriazolinone 4 has been synthesised in a single step via the novel condensation of semicarbazide hydrochloride with orthoester 8. Alkylation of secondary amine 3 with compound 4 proceeds in 99% yield to afford the target NK1 antagonist 1.
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1639725
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