Title of article
Lipase-catalyzed kinetic resolution of racemic seven-membered substituted lactones
Author/Authors
Shioji، نويسنده , , Kosei and Matsuo، نويسنده , , Ayako and Okuma، نويسنده , , Kentaro and Nakamura، نويسنده , , Kaoru and Ohno، نويسنده , , Atsuyoshi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
8799
To page
8802
Abstract
Optically active 3-, 4-, 5-, or 6-methyl substituted seven-membered lactones were prepared by Candida antarctica lipase (CAL)-catalyzed kinetic resolution of the racemic lactones. Among these lactones, only in the case of 5-methylhexanolide (R)-isomer reacts faster than the other enantiomer, while the rest of lactones show (S)-selectivity.
Keywords
enzymes and enzyme reaction , Hydrolysis , lactone
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1639836
Link To Document