Title of article
New phenylfluorenyl based linkers for solid phase synthesis
Author/Authors
Bleicher، نويسنده , , Konrad H and Lutz، نويسنده , , Christian and Wüthrich، نويسنده , , Yves، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
6
From page
9037
To page
9042
Abstract
The synthesis of 9-(4-hydroxyphenyl)-9-H-fluoren-9-ol and 5-(4-(9-hydroxy-9H-fluoren-9-yl)-phenoxy)-pentanoic acid and their applications as new linkers for solid phase synthesis is reported. These supports show higher acid stability compared to standard trityl resins. Carboxylic acids and amines are immobilized and cleaved off after further modifications. TFA treatment releases the products in high yield and excellent purity.
Keywords
linkers , Solid phase synthesis , peptide synthesis , inverse peptide synthesis , 2-aminothiazoles
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1639997
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