Title of article
New methods for the stereoselective synthesis of 2-hydroxy-3,4-dienoates and functionalized 2,5-dihydrofurans
Author/Authors
Krause، نويسنده , , Norbert and Laux، نويسنده , , Michael and Hoffmann-Rِder، نويسنده , , Anja، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
9613
To page
9616
Abstract
Titanium enolates of 3,4-dienoates 3 were formed by treatment with LDA and Cp2TiCl2 and oxidized with dimethyl dioxirane to furnish the allenic hydroxyesters 4 with up to 90% diastereoselectivity. Smooth cyclization to the functionalized 2,5-dihydrofurans 5 was accomplished with complete axis to center chirality transfer by treatment with HCl gas in chloroform.
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1640373
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