Title of article
Total synthesis and biological evaluation of apicularen A and synthetic analogs
Author/Authors
Bhattacharjee، نويسنده , , Ashoke and Seguil، نويسنده , , Olga R and De Brabander، نويسنده , , Jef K، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
4
From page
1217
To page
1220
Abstract
The first total synthesis of the potent cytostatic agent apicularen A is described along with the synthesis of the corresponding C11-epimers and side chain modified congeners. Growth inhibition experiments with the human melanoma cancer cell line SK-MEL-5 revealed an important role for the unusual N-acyl enamide side chain.
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1641869
Link To Document