Title of article
Rapid microwave-enhanced synthesis of 4-hydroxyquinolinones under solvent-free conditions
Author/Authors
Lange، نويسنده , , Jos H.M and Verveer، نويسنده , , Peter C and Osnabrug، نويسنده , , Stefan J.M and Visser، نويسنده , , Geb M، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
3
From page
1367
To page
1369
Abstract
3-Aryl-4-hydroxyquinolin-2(1H)-ones are potent and selective glycine-site NMDA receptor antagonists of pharmaceutical interest. A novel microwave-enhanced synthesis of such quinolinones under solvent-free conditions has been developed. The quinolinones are easily obtained in a one-pot procedure as a result of the formal amidation of a malonic ester derivative with an aniline and subsequent cyclisation of the intermediate malondianilides.
Keywords
microwave heating , quinolinones , anilides , MDL-104 , 653
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1641997
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