Synthesis of biologically active N2-amine adducts of 2′-deoxyguanosine

Several biologically important N2-adducts of 2′-deoxyguanosine (dG) that previously were difficultly accessible, have been synthesized directly by means of the Buchwald–Hartwig reaction. The reaction employed in each case involves the coupling of 2′-deoxy-2-bromoinosine with the appropriate amine. Deprotection in all cases gave good yields of the desired 2-alkylated or -arylated deoxynucleoside.