A novel core-shell type polymer support for solid-phase peptide synthesis

Novel core-shell type resins with a highly cross-linked polystyrene (PS) core and a poly(ethylene glycol) (PEG) shell were prepared by suspension polymerization for use in solid-phase synthesis. All the resins were of bead type with a diameter of 50–200 μm. The loading capacities of the amino groups were 0.05–0.2 mmol/g resin and the thickness of the PEG shell was 2–4 μm. Compared with the other resins such as 1% cross-linked PS resin and TentaGel resin, the resins showed excellent performance in photolytic release of peptide product from photolabile linker.