Title of article
A new facile synthesis of 2-aminothiazole-5-carboxylates
Author/Authors
Zhao، نويسنده , , Rulin and Gove، نويسنده , , Stacey and Sundeen، نويسنده , , Joseph E and Chen، نويسنده , , Bang-Chi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
2
From page
2101
To page
2102
Abstract
A new facile method has been developed for the synthesis of 2-aminothiazole-5-carboxylates. The new method involves reaction of ethyl β-ethoxyacrylate with N-bromosuccinimide (NBS) to give a novel intermediate, α-bromo-α-formylacetate hemiacetal. Cyclization of the in situ formed hemiacetal with thioureas afforded 2-aminothiazole-5-carboxylates in 60–98% yields.
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1643748
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