Title of article
Conformationally restricted glutamic acid derivatives: asymmetric synthesis of 4-substituted 4,5-dihydro-3(2H)-pyridazinones
Author/Authors
Carlos Alvarez-Ibarra، نويسنده , , Carlos and Cs?k?، نويسنده , , Aurelio G and G?mez de la Oliva، نويسنده , , Cristina Jiménez-Rodriguez، نويسنده , , Eliazar، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
3
From page
2129
To page
2131
Abstract
The synthesis of optically pure 4,5-dihydro-3(2H)-pyridazinones substituted at C-4, which can be considered conformationally restricted cyclic Glu derivatives, has been accomplished by the asymmetric γ-alkylation of α,β-unsaturated glutamyl sultams under PTC conditions followed by reaction with hydrazines.
Keywords
Alkylation , amino acids and derivatives , cyclization , Pyridazinones , sultams
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1643763
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