Title of article
First chemo- and stereoselective reduction of imines using trichlorosilane activated with N-formylpyrrolidine derivatives
Author/Authors
Iwasaki، نويسنده , , Fumiaki and Onomura، نويسنده , , Osamu and Mishima، نويسنده , , Katsuhiko and Kanematsu، نويسنده , , Takefumi and Maki، نويسنده , , Toshihide and Matsumura، نويسنده , , Yoshihiro، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
3
From page
2525
To page
2527
Abstract
Trichlorosilane activated with N-formylpyrrolidine derivatives was found to be an effective reagent for reduction of imines to amines. The reagent showed much higher selectivity toward imino groups than carbonyl groups. The reduction of imines using trichlorosilane activated with optically active N-formylproline derivatives gave enantiomerically enriched amines in moderate optical yields (up to 66% ee).
Keywords
Amines , imines , silicon halides , Reduction
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1644006
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