Title of article
Asymmetric synthesis of α-substituted propynyl amines. Application to the preparation of a polysubstituted dihydroisoindoline framework
Author/Authors
Blanchet، نويسنده , , Jérôme and Bonin، نويسنده , , Martine and Micouin، نويسنده , , Laurent and Husson، نويسنده , , Henri-Philippe Husson، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
3
From page
3171
To page
3173
Abstract
A new route towards the asymmetric preparation of α-substituted propynylamines has been developed. The key step involved a diastereoselective addition of diethylalkynylaluminum to oxazolidines derived from R-(−)-phenylglycinol. The use of this reaction for the rapid preparation of a polysubstituted isoindoline framework is described.
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1644559
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