New polyoxyalkyleneamine-grafted paramagnetic supports for solid-phase synthesis and bioapplications

The synthesis of some novel polyoxyalkyleneamine grafted paramagnetic supports for use in chemical and biological applications is described. These composite supports were synthesized by utilizing power ultrasound to enhance the level of incorporation of certain high molecular weight, polyoxyalkyleneamine (Jeffamine®) polymers into the matrix of a chloromethylated paramagnetic support. These new composite paramagnetic supports show excellent expansion properties in both organic solvents and water. The use of these grafted supports for multi-step solid-phase synthesis was then demonstrated by example.