Single electron transfer approaches to the practical synthesis of aromatic and heterocyclic-CF2H derivatives

Single electron transfer (SET) approaches with organic reductants such as sodium hydroxymethanesulfinate (Rongalite®), sodium dithionite (regarded as precursors of sulfoxylate radical anion) and tetrakis(dimethylamino)ethylene (TDAE) were employed for the reductive dehalogenation of a series of halogeno-difluoromethylated aromatics and heterocycles, and for the practical synthesis of the corresponding difluoromethylated derivatives.