Title of article
cis-Fused hexahydro-4aH-indeno[1,2-b]pyridines: transformation of bridgehead ester group and conversion to tricyclic analogues of NK-1 and dopamine receptor ligands
Author/Authors
De Wit، نويسنده , , Tom and Van Emelen، نويسنده , , Kristof and Maertens، نويسنده , , Faye and Hoornaert، نويسنده , , Georges J and Compernolle، نويسنده , , Frans، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
4
From page
4919
To page
4922
Abstract
The bridgehead ester group of cis-fused methyl 2-oxo-9b-phenyl-1,2,3,4,5,9b-hexahydro–4aH-indeno[1,2-b]pyridine-4a-carboxylates obtained via an intramolecular Ritter reaction, was transformed into acid, alcohol, aldehyde, and amine groups. Further elaboration afforded conformationally constrained tricyclic analogues of NK-1 antagonists and a bicyclic dopamine receptor ligand.
Keywords
piperidinones , Curtius reaction , Aldehydes , diamines
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1645911
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