Title of article
New non-ionic, highly water-soluble derivatives of C60 designed for biological compatibility
Author/Authors
Wharton، نويسنده , , Tim and Kini، نويسنده , , Vinay U and Mortis، نويسنده , , Rachel A. and Wilson، نويسنده , , Lon J، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
4
From page
5159
To page
5162
Abstract
The most water-soluble (>240 mg C60 mL−1) fullerene derivatives to date, the new malonodiserinolamide fullerenes C60[C(COSer)2]n (n=4, 5, 6, Ser=2-amino-1,3-propanediol), have been synthesized and characterized. The compounds were designed to provide maximum water solubility and biological compatibility. The facile synthesis is based on Bingel additions to C60 and should be applicable to the solubilization of any prospective fullerene-based drug.
Keywords
Fullerenes , water-soluble fullerenes , Fullerene derivatives
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1646074
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