Title of article
Synthesis of β-d-Galp-(1→4)-α-d-Manp methanephosphonate, a substrate analogue for the elongating α-d-mannosyl phosphate transferase in the Leishmania
Author/Authors
Borodkin، نويسنده , , Vladimir S and Ferguson، نويسنده , , Michael A.J and Nikolaev، نويسنده , , Andrei V، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
4
From page
5305
To page
5308
Abstract
An isosteric C-glycoside phosphono analogue of dec-9-enyl β-d-galactopyranosyl-(1→4)-α-d-mannopyranosyl phosphate was synthesised and showed high biological activity in the Leishmania MPT assay. A one-step Horner–Emmons/Michael reaction was developed for the stereoselective preparation of α-d-mannosyl methanephosphonate derivatives.
Keywords
carbohydrates , phosphonic acids and derivatives
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1646181
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