Title of article
A shortcut to the smaller fragment of pamamycin-607
Author/Authors
Bernsmann، نويسنده , , Heiko and Gruner، نويسنده , , Margit and Frِhlich، نويسنده , , Roland and Metz، نويسنده , , Peter، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
4
From page
5377
To page
5380
Abstract
Starting from a key intermediate for the synthesis of the larger hydroxy acid constituent of pamamycin-607 (1), an efficient three-step route to the methyl ester of the smaller fragment of 1 involving a Yamaguchi lactonization with concomitant C(2) epimerization was developed. Alternatively, the methyl ester of the smaller hydroxy acid portion of 1 was prepared by direct C(2) epimerization.
Keywords
antibiotics , medium-ring heterocycles , Epimerisation , Yamaguchi lactonisation
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1646239
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