Title of article
Indium-mediated diastereoselective allylation reactions: preparation of tert-α-hydroxy acids
Author/Authors
Shin، نويسنده , , Jeong Ah and Cha، نويسنده , , Joo Hwan and Pae، نويسنده , , Ae Nim and Choi، نويسنده , , Kyung Il and Koh، نويسنده , , Hun Yeong and Kang، نويسنده , , Han-Young and Cho، نويسنده , , Yong Seo، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
4
From page
5489
To page
5492
Abstract
Indium-mediated allylation reactions of α-ketoimides derived from Oppolzerʹs sultam were accomplished in aqueous THF in good yields and excellent diastereomeric excesses. It could be a useful method for the preparation of enantiopure t-α-hydroxy acids. When the substituent of α-ketoimides was changed from phenyl to thiophenyl or furyl group, diastereoselectivity decreased in comparison to N-phenyl derivatives, but changing solvent to aqueous ethanol provided improved levels of diastereoselectivity.
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1646336
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