Synthesis and hydrolytic stability of 5′-aminoacylated oligouridylic acids

Dimers and trimers of uridylic acid with a phenylalanine residue at their 5′-terminus were prepared in solution via intermediates with acid-labile protecting groups. A 5′-aminoacylated octanucleotide was prepared on solid support using a phosphoramidate linker and an allyloxycarbonyl-protected phenylalanine.