Title of article
N-Aroyloxynaphthalimides as novel highly efficient DNA photocleavers: substituent effects
Author/Authors
Qian، نويسنده , , Xuhong and Yao، نويسنده , , Wei and Chen، نويسنده , , Gang and Huang، نويسنده , , Xiayu and Mao، نويسنده , , Ping، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
4
From page
6175
To page
6178
Abstract
A novel DNA photocleaver family of N-benzoyloxythioxonaphthalimides, which show improved DNA intercalation and photocleaving activity compared with their oxo- counterparts, were synthesized and evaluated. The substituents on the benzene ring of the benzoyloxy moiety have an important and unusual influence on the DNA photocleaving activity. N-(p-Methoxylbenzoyloxy)thioxonaphthalimide is able to photocleave DNA at low concentration (5 μM) with ‘time-resolved’ and pH independent properties.
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1646842
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