Title of article
A new facile method for the stereoselective synthesis of trans-2-aryl-3,3-dimethylcyclopropane-1-carboxylic acids
Author/Authors
Chen، نويسنده , , Bang-Chi and Ngu، نويسنده , , Khehyong and Guo، نويسنده , , Peng and Liu، نويسنده , , Wen and Sundeen، نويسنده , , Joseph E and Weinstein، نويسنده , , David S and Atwal، نويسنده , , Karnail S and Ahmad، نويسنده , , Saleem، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
3
From page
6227
To page
6229
Abstract
A new facile method for the preparation of trans-2-aryl-3,3-dimethylcyclopropane-1-carboxylic acids was developed. The new method involved [2+2]-cycloaddition of styrenes with N,N,2-trimethylpropionamide followed by bromination and rearrangement of the resulting 3-aryl-2,2-dimethylcyclobutanones, affording the title compounds in two steps in 60–84% overall yields.
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1646886
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