Title of article
Remarkable stereoselectivity in the alkylation of a hydroazulenone: progress towards the total synthesis of guanacastepene
Author/Authors
Dudley، نويسنده , , Gregory B and Tan، نويسنده , , Derek S and Kim، نويسنده , , Guncheol and Tanski، نويسنده , , Joseph M and Danishefsky، نويسنده , , Samuel J، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
3
From page
6789
To page
6791
Abstract
exo-Methylene ketone 6 serves as a vehicle for elaboration of the C8 quaternary center en route to guanacastepene via a conjugate addition–alkylation sequence. Methylation of the cycloheptadienolate derived from 7 is highly selective for the desired relative stereochemistry, as determined by NMR and crystallographic analysis.
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1647259
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