Title of article
HIV-1 replication inhibitors of the styrylquinoline class: incorporation of a masked diketo acid pharmacophore
Author/Authors
Zouhiri، نويسنده , , Fatima and Desmaële، نويسنده , , Didier and dʹAngelo، نويسنده , , Jean and Ourevitch، نويسنده , , Michèle and Mouscadet، نويسنده , , Jean-François and Leh، نويسنده , , Hervé and Le Bret، نويسنده , , Marc، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
4
From page
8189
To page
8192
Abstract
A novel variant of HIV-1 replication inhibitors of the styrylquinoline class, bearing an α-keto acid appendage at C-7, has been synthesized. Though completely inactive in in vitro experiments against HIV-1 integrase, this compound exhibited a significant antiviral activity (IC50=10 μM).
Keywords
antivirals , Enzyme inhibitors , Quinolines , thioacetals , keto acids and derivatives
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1648108
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