Title of article
Cleavage of the N(1)C(4) bond of 4-(4′-hydroxyphenyl)-azetidine-2-ones via quinone methide intermediates
Author/Authors
Cabell، نويسنده , , Larry A and Hedrich، نويسنده , , Loren W and McMurray، نويسنده , , John S، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
5
From page
8409
To page
8413
Abstract
In this paper we describe a novel ring-opening reaction in which 4-(4′-hydroxyphenyl)-azetidine-2-ones, on treatment with base, rearrange to quinone methide intermediates with concomitant cleavage of the C(4)N(1) bond. The quinone methide intermediate serves as a substrate for Michael-type 1,6 conjugate additions.
Keywords
6 conjugate addition , 1 , ?-Lactam , quinone methide
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1648277
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