Title of article
Mild deprotection of 2-(trimethylsilyl)ethyl esters
Author/Authors
Serrano-Wu، نويسنده , , Michael H and Regueiro-Ren، نويسنده , , Alicia and St. Laurent، نويسنده , , Denis R and Carroll، نويسنده , , Tina M and Balasubramanian، نويسنده , , Balu N، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
3
From page
8593
To page
8595
Abstract
A method for the deprotection of 2-(trimethylsilyl)ethyl (TMSE) esters is described. Treatment of carboxylic esters with NaH in DMF cleanly produces the deprotected acid after extractive work-up. This method can be applied to sterically-hindered substrates as well as esters containing fluoride-labile functionality. A tandem alkylation/ester deprotection procedure is also presented.
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1648437
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