Title of article
A convenient route to α-amino acids with β-alkyne substituents from a serine derived aziridine
Author/Authors
Turner، نويسنده , , John J and Leeuwenburgh، نويسنده , , Michiel A and van der Marel، نويسنده , , Gijs A. and van Boom، نويسنده , , Jacques H، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
4
From page
8713
To page
8716
Abstract
1-[(S)-1-(2-Nitrobenzenesulfonyl)-aziridin-2-yl]-4-methyl-2,6,7-trioxabicyclo[2.2.2]octane 5 was ring opened regioselectively with a variety of lithium acetylides to give α-amino acids bearing γ,δ-unsaturation in very good to excellent yields. The 2-nitrobenzenesulfonyl and OBO ester protecting groups were removed in excellent overall yield.
Keywords
Carbon nucleophiles , nitrobenzenesulfonamides , aziridine , Ring opening , Mitsunobu reaction
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1648531
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