Title of article
One-pot highly stereoselective reduction of β-keto amides to syn-γ-aminols
Author/Authors
Bartoli، نويسنده , , Giuseppe and Bosco، نويسنده , , Marcella and Dalpozzo، نويسنده , , Renato and Marcantoni، نويسنده , , Enrico and Massaccesi، نويسنده , , Massimo and Rinaldi، نويسنده , , Samuele and Sambri، نويسنده , , Letizia، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
5
From page
8811
To page
8815
Abstract
In the presence of titanium tetrachloride, the borane/tetrahydrofuran complex can reduce 2-methyl-3-oxoamides into the corresponding syn-aminols in good yields and high diastereoselectivity. The use of borane/dimethyl sulfide instead of BH3/THF allows a partial reduction to syn-β-hydroxyamides.
Keywords
Aminoalcohols , diastereoselection , hydroxy amides , Boranes , TiCl4
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1648607
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