Title of article
Boron-mediated aldol reactions of ethyl α-(N,N)-dibenzylamino ketones: control of enolisation geometry and aldehyde π-facial selectivity
Author/Authors
Paterson، نويسنده , , Ian R. Mackay، نويسنده , , Angela C، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
4
From page
9269
To page
9272
Abstract
The boron-mediated aldol reactions of a range of chiral α-(N,N)-dibenzylamino ketones with aldehydes can be controlled to provide stereodefined adducts. Complementary induction can be achieved with cHex2BCl/Me2NEt leading to preferential formation of the 1,2-anti-2,4-syn adducts, while Bu2BOTf/iPr2NEt provides 1,2-syn-2,4-anti adducts.
Keywords
boron aldol , amino acids , amino ketones , Libraries , stereoinduction
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1648958
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