Title of article
Isoprenoid biosynthesis via the methylerythritol phosphate pathway: accumulation of 2-C-methyl-d-erythritol 2,4-cyclodiphosphate in a gcpE deficient mutant of Escherichia coli
Author/Authors
Seemann، نويسنده , , Myriam and Campos، نويسنده , , Narciso and Rodr??guez-Concepci?n، نويسنده , , Manuel and Hoeffler، نويسنده , , Jean-François and Grosdemange-Billiard، نويسنده , , Catherine and Boronat، نويسنده , , Albert and Rohmer، نويسنده , , Michel، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
4
From page
775
To page
778
Abstract
In the bacterium Escherichia coli, gcpE is an essential gene in the methylerythritol phosphate pathway for isoprenoid biosynthesis. Incubation of [1-3H]methylerythritol with an E. coli mutant defective in the gcpE gene resulted in the accumulation of [1-3H]methylerythritol 2,4-cyclodiphosphate. This suggests that the GCPE protein is involved in the further conversion of methylerythritol cyclodiphosphate into isoprenoids.
Keywords
2-C-methyl-d-erythritol 4-phosphate , 2-C-methyl-d-erythritol 2 , 4-cyclodiphosphate , Isoprenoids , gcpE , Biosynthesis
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1649548
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