Title of article
Asymmetric synthesis of both enantiomers of two acyclic nucleoside analogues related to d4T and acyclovir
Author/Authors
Ewing، نويسنده , , David F and Glaçon، نويسنده , , Virginie and Mackenzie، نويسنده , , Grahame and Len، نويسنده , , Christophe، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
3
From page
989
To page
991
Abstract
The enantiomers of 1-{[(2-hydroxy-1-phenyl)ethoxy]methyl}thymine and 9-{[(2-hydroxy-1-phenyl)ethoxy]methyl}guanine have been obtained in high yield in five steps from (R)- and (S)-1-phenylethan-1,2-diol. These chiral compounds are acyclic nucleoside analogues of d4T and acyclovir, respectively.
Keywords
Acyclovir , Asymmetric dihydroxylation , d4T , acyclic nucleosides
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1649706
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